A pharmaceutical composition for use in a method for liver regeneration or for enhancement of the liver performance comprises the vitamins B6, B9, and B12 in the daily doses: B6 not less than 4 mg, optionally not more than 500 mg； B9 not less than 0.6 mg, optionally not more than 15 mg； B12 not less than 0.008 mg, optionally not more than 4 mg.
