A pharmaceutical composition for use in a method for liver regeneration or for increasing liver performance contains vitamins B6, B9 and B12 in the daily dosages: B6 not less than 4 mg, optionally not more than 500 mg; B9 not less than 0.6 mg, optionally not more than 15 mg; B12 not less than 0.008 mg, optionally not more than 4 mg.