ACADEMY OF SCIENCES OF THE CZECH REPUBLIC;INSTITUTE OF EXPERIMENTAL BOTANY
发明人:
SZUCOVA, LUCIE,ZATLOUKAL, MAREK,SPICHAL, LUKAS,VOLLER, JIRI,DOLEZAL, KAREL,STRNAD, MIROSLAV,MASSINO, FRANK J.
申请号：
ES08866388
公开号：
ES2463997T3
申请日:
2008.12.24
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
6,9-disubstituted purine derivatives of the general formula I ** Formula ** and their pharmaceutically acceptable salts, wherein R 6 is an alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocycle, heterocycloalkyl, heteroalkyl or arylalkyl group containing the minus a hydroxyl substitution therein, and wherein R9 is a tetrahydropyran-2-yl, tetrahydrofuran-2-yl, 4-chlorobutyl or 1-ethoxyethyl group； wherein alkyl indicates a branched or unbranched alkyl chain containing from 1 to 8 carbon atoms, which is optionally independently substituted with from 1 to 7 substituents selected from the group consisting of hydroxyl, halogen, alkyloxy, a riloxyl, alkylamino , arylamino, amino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulfo, sulfamido, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl, alkyloxycarbonylamino, aryloxycarbonylamino, aryl, heterocycle and heteroaryl； wherein alkenyl indicates a branched or unbranched alkenyl chain containing from 2 to 7 carbon atoms with at least one double bond therein, which is optionally independently substituted with from 1 to 6 substituents selected from the group containing halogen, hydroxyl, alkyloxy, aryloxy, amino, alkylamino, arylamino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl, aryloxycarbonylamino and alkyloxycarbonylamino groups, in which alkynyl indicates a chain of branched or unbranched alkynyl containing from 2 to 7 carbon atoms with at least one triple bond therein, which is optionally independently substituted with from 1 to 6 substituents selected from the group consisting of halogen, hydroxyl group, alkyloxy, aryloxy , amino, alkylamino, arylamino, mercapto, carboxyl, cyano, nitro, carbamoyl, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylthio, arylthio, cycloalkyl, alkyloxycarbonylamino and aryloxycarbonylamino； wherein cycloalkyl indicates a monocyclic or polycyclic alkyl group containing from 3 to 15 carbon atoms, which is optional
