ALMANZAR, Giovanni,BLEY, Thorsten,KÖSTLER, Herbert,PRELOG, Martina,WECH, Tobias,GUTJAHR, Fabian,JAKOB, Peter Michael,KÜRTEN, Stefanie
申请号：
EPEP2017/066315
公开号：
WO2018/007258A1
申请日:
2017.06.30
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The invention concerns immune complexes for use in a diagnostic method for de- tecting and localizing specific cells or a structure of a tissue in a human or animal body by an imaging technique. First antibodies are directed to an antigen located on the tissue or on the surface of said cells. The first antibodies are optionally la- beled with first labels. The method comprises that the first antibodies and second antibodies directed to said first antibodies or to the first labels or the first antibod- ies and ligands specifically binding to the first labels are administered to said hu- man or animal body, wherein said second antibodies or said ligands are labeled with second labels detectable by said imaging technique. The structure of the tis- sue or the cells is/are detected and localized in the human or animal body after ad- ministration of the first antibodies and second antibodies or of the first antibodies and the ligands by use of the imaging technique. The immune complexes of the in- vention are formed from the first antibodies and the second antibodies or from the first antibodies and the ligands ex vivo before administration of said immune com- plexes to the human or animal body. The ratio of said second antibodies to said first antibodies or of said ligands to said first antibodies in the immune complexes is at least 5 : 1.La présente invention concerne des complexes immuns destinés à être utilisés dans un procédé de diagnostic pour détecter et localiser des cellules spécifiques ou une structure d'un tissu dans un corps humain ou animal par une technique d'imagerie. Les premiers anticorps sont dirigés vers un antigène situé sur le tissu ou sur la surface desdites cellules. Les premiers anticorps sont éventuellement des premiers marqueurs avec des premières étiquettes. Le procédé comprend les étapes suivantes : les premiers anticorps et les seconds anticorps dirigés contre lesdits premiers anticorps ou les premiers marqueurs, ou encore contre les premiers
