Shulan SU,Jinao DUAN,Dawei QIAN,Yue ZHU,Hui YAN,Xinxin DAI
申请号：
US16236403
公开号：
US20190381082A1
申请日:
2018.12.29
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed is an application of verbascoside in the preparation of drugs for preventing and treating type II diabetic nephropathy. The protective effect of verbascoside on type II diabetic nephropathy and the action mechanism thereof are also included in the invention. The results show that verbascoside may improve liver injuries caused by high glucose, and reduce levels of serum creatinine, urea nitrogen, microalbuminuria and blood lipid (total cholesterol and triglyceride), fasting blood sugar and serum insulin in spontaneous diabetic db/db mice, and significantly reduce expressions of TGF-β1 and its signal transduction protein Smad3 and Smad4 and α-SMA in kidney tissues. Meanwhile, verbascoside may improve liver injuries caused by high glucose, and inhibit HK-2 proliferation and EMT formation. In conclusion, verbascoside induces significant protection on type II diabetic nephropathy, and its action mechanism is to protect kidney by regulating oxidative stress response, inhibiting TGF-β/smad signal pathways and improving renal fibrosis.
