Cosmetic facial treatment delivery system with skincare benefit agents and iontophoresis micro-current zones are provided for delivering skincare treatments to multiple targeted areas of the skin to treat different concerns of an individual user. The system includes a sheet substrate with skincare agents and a reduction agent. An activating cream is applied to the skin along with the sheet substrate. The activating cream includes an oxidation agent. The combined reduction agent of the sheet substrate and the oxidation agent of the activating cream cause a redox reaction to generate micro-current. The micro-current generated facilitates delivery of skin benefit agents from the sheet by iontophoresis, or directly affects treatment by delivery of iontophoresis micro-current to the skin.
