Cosmetic facial treatment delivery system with skincare benefit agents and iontophoresis micro-current zones are provided for delivering skincare treatments to multiple targeted areas of the skin to treat different concerns of an individual user. The system includes a sheet substrate with skincare agents and a dual-phase cream that generates micro-current when activated. A first phase contains a reduction agent and a second phase contains an oxidation agent. The cream is activated to produce micro-current when the two phases are combined. The cream is applied to skin along with the sheet substrate. The micro-current generated facilitates delivery of skin benefit agents from the sheet by iontophoresis, or directly affects treatment by delivery of iontophoresis micro-current to the skin.
