To obtain a hollow fiber membrane type blood purifier which has high blood compatibility and excellent antioxidation performance and is capable of retaining highly stable antioxidation performance even in a severe environment. A hollow fiber membrane type blood purifier provided with a hollow fiber membrane, said hollow fiber membrane comprising a polysulfone-based resin, polyvinylpyrrolidone, a fat-soluble vitamin and an ester group-containing polymer, wherein: the content of the fat-soluble vitamin on the whole surface of the hollow fiber membrane is 2-18 mg inclusive per gram of the hollow fiber membrane； when the hollow fiber membrane is extracted with ethanol and, after drying the extract to solidness, the infrared absorption spectrum (IR) thereof is measured, the ratio of the absorbance [Abs(A)] at peak (A) around 1720-1730 cm-1 to the absorbance [Abs(B)] at peak (B) around 1660-1670 cm-1 [Abs(A)/Abs(B)] is 0.01-0.3 inclusive； and the moisture content of the hollow fiber membrane is 0-600 mass% inclusive.本發明係獲得一種血液相容性、抗氧化性能優異，即便於嚴酷環境下抗氧化性能之穩定性亦較高的中空纖維膜型血液淨化裝置。本發明之中空纖維膜型血液淨化裝置包含中空纖維膜，該中空纖維膜含有聚碸系樹脂、聚乙烯吡咯啶酮、脂溶性維生素、及具有酯基之聚合物，且上述中空纖維膜之整個表面中上述脂溶性維生素之存在量係每1 g上述中空纖維膜為2 mg以上18 mg以下，利用乙醇萃取上述中空纖維膜，使萃取液乾固後測定紅外線吸收光譜(IR)時，1720~1730 cm-1附近之波峰A之吸光度(Abs(A))、與1660~1670 cm-1附近之波峰B之吸光度(Abs(B))的比(Abs(A)/Abs(B))為0.01以上0.3以下，上述中空纖維膜之水分率為0質量%以上600質量%以下。
