In one aspect, provided herein are methods and compositions for treating breast cancer in a patient using 4-iodo-3-nitrobenzamide, a metabolite thereof, or a pharmaceutically acceptable salt thereof in combination gemcitabine and carboplatin. In another aspect, provided herein are methods and compositions for treating breast cancer in a patient using 4-iodo-3- nitrobenzamide, a metabolite thereof, or a pharmaceutically acceptable salt thereof in combination paclitaxel.