Disclosed is the use of a pharmaceutical composition comprising a first component formulated for immediate-release and a second component formulated for extended-release in the manufacture of a medicament for treating nocturia in a subject in need thereof, wherein said first component and said second component each comprises acetaminophen, and wherein said acetaminophen in said first component and said second component is present in an amount of 5 mg to 2000 mg, and further wherein said first component and/or said second component further comprises an antidiuretic agent such as desmopressin; and wherein said first component and/or said second component optionally further comprises an antimuscarinic agent selected from the group consisting of oxybutynin, solifenacin, darifenacin and atropine; and/or optionally further comprises one or more spasmolytics.