Stable and aggregation free antibody FC molecules through CH3 domain interface engineering

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专利权人:

Gunasekaran Kannan;Hongxing Zhou

发明人:

Gunasekaran Kannan,Hongxing Zhou

申请号：

US13382876

公开号：

US09308258B2

申请日:

2010.06.29

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention relates to methods of increasing stability and reducing aggregation in compositions comprising antibody Fc molecules and to composition comprising such molecules. Certain amino acid substitutions in the CH3 domain result in increased stability and reduced aggregation of compositions containing polypeptides comprising a CH3 domain, e.g., an antibody or Fc-fusion protein.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/