The present invention relates to immunoglobulins that bind ADAMTSS and more in particular to polypeptides, that comprise or essentially consist of one or more such immunoglobulins. The invention also relates to constructs comprising such immunoglobulins, such as immunoglobulin single variable domains (ISVDs) or polypeptides as well as nucleic acids encoding such immunoglobulins or polypeptides； to methods for preparing such immunoglobulins, polypeptides and constructs； to host cells expressing or capable of expressing such immunoglobulins or polypeptides； to compositions, and in particular to pharmaceutical compositions, that comprise such immunoglobulins, polypeptides, constructs, nucleic acids and/or host cells； and to uses of immunoglobulins, polypeptides, constructs, nucleic acids, host cells and/or compositions, in particular for prophylactic and/or therapeutic purposes, such as the prophylactic and/or therapeutic purposes mentioned herein. Other aspects, embodiments, advantages and applications of the invention will become clear from the further description herein.La présente invention concerne des immunoglobulines qui se lient aux ADAMTS5 et plus particulièrement des polypeptides qui comprennent ou consistent essentiellement en une ou plusieurs de ces immunoglobulines. L'invention concerne également des constructions comprenant de telles immunoglobulines, par exemple des domaines variables uniques d'immunoglobuline (ISVD) ou des polypeptides, ainsi que des acides nucléiques codant pour ces immunoglobulines ou polypeptides ； des procédés de préparation de ces immunoglobulines, polypeptides et constructions ； des cellules hôtes exprimant ou capables d'exprimer ces immunoglobulines ou polypeptides ； des compositions, et en particulier des compositions pharmaceutiques, qui comprennent ces immunoglobulines, polypeptides, constructions, acides nucléiques et/ou cellules hôtes ； et des utilisations d'immunoglobulines, de polypeptides, de constructions, d'acides nuclé
