A lymphocyte population T diverted with a regulatory phenotype (T cells Redirected), T cells being redirected equipped with specificity to an antigen or target ligand, the antigen or target ligand is one which is present or expressed in a site or tissue response immune or inflammatory unwanted whose cells each comprising a chimeric nucleic acid molecule is expressed in a single continuous chain, a chimeric receptor polypeptide comprising a region of extracellular recognition, a transmembrane region and a region of intracellular signaling, such that the extracellular region of the same is displayed on the surface of said cells, wherein said chimeric nucleic acid molecule comprising: (a) a first nucleic acid segment comprising a sequence encoding said region of extracellular recognition specific for said antigen or target ligand, which region no It comprising an extracellular domain of MHC protein and wherein said antigen binding region or target ligand in a non-MHC restricted manner to or in a manner not dependent MHC (B) a second nucleic acid segment comprising a sequence encoding said transmembrane region and (c) a third nucleic acid segment comprising a sequence encoding said intracellular signaling region comprising a combination of polypeptide fractions of T-cell signalingUna población linfocitos T redirigidos con un fenotipo regulador (células T redirigidas), estando las células T redirigidas dotadas con especificidad hacia un antígeno o ligando objetivo, cuyo antígeno o ligando objetivo es uno que está presente o expresado en un sitio o tejido de una respuesta inmune o inflamatoria no deseada, cuyas células comprenden cada una, una molécula quimérica de ácido nucleico que se expresa, en una cadena continua única, un polipéptido receptor quimérico que comprende una región de reconocimiento extracelular, una región transmembrana y una región de señalización intracelular, de tal manera que la región extracelular de la mismos se despliega sobre la superficie de di
