Anil K. Sood,Andras G. Lacko,Gabriel Lopez-Berestein,Lingegowda S. Mangala,Walter J. McConathy,Laszlo Prokai,Maya P. Nair
申请号：
US13129349
公开号：
US08734853B2
申请日:
2009.11.17
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are high density lipoprotein-nucleic acid particles, wherein the particles include (a) an apolipoprotein (b) a nucleic acid component comprising a therapeutic nucleic acid segment and (c) a polypeptide comprising a positively charged region, wherein the positively-charged region of the polypeptide associates with the nucleic acid component. Also disclosed are pharmaceutical compositions that include a) an apolipoprotein (b) a nucleic acid component comprising a therapeutic nucleic acid segment and (c) a polypeptide comprising a positively charged region. Methods that concern the particles and pharmaceutical compositions of the present invention are also set forth, as well as kits.
