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Quantification of misfolded TNFR2:Fc
专利权人:
发明人:
Alfred Rupprechter,Michael Fuchs,Johann Holzmann,William Lamanna,Christoph Posch,Hansjorg Toll,Robert Mayer
申请号:
US14516992
公开号:
US09182410B1
申请日:
2014.10.17
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention is directed to methods for determining the relative amount of wrongly disulphide bridged TNFR2:Fc in a sample of TNFR2:Fc, a fusion protein which is used in a variety of therapeutic applications. In addition, the invention pertains to a method for purifying TNFR2:Fc using said method for determining the percentage of wrongly disulphide bridged TNFR2:Fc, and to TNFR2:Fc compositions obtained thereby.
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