VRANDERICK, MANON,ST-ONGE, JEAN-LUC,GEDEON, CHRISTELLE,GALLO, MICHELE,GERVAIS, ERIC
申请号：
CA2848798
公开号：
CA2848798C
申请日:
2013.02.18
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
A dual release oral dosage system/dosage form comprising an immediate release component/composition and a delayed release component/composition is described. Each of the immediate release component/composition and delayed release component/composition comprises one or more of doxylamine, an analog thereof, a derivative thereof, a prodrug thereof, a metabolite thereof and/or a salt thereof, and one or more of pyridoxine, a salt thereof, a metabolite thereof and/or a salt of the metabolite. The dual release oral dosage system/dosage form exhibits an improved pharmacokinetic profile relative to the current Diclectin® formulation and is useful for example for the alleviation of the symptoms of nausea and vomiting, for example in the case of nausea and vomiting in pregnancy (NVP).
