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КОМПОЗИЦИИ СВ-183,315 И ОТНОСЯЩИЕСЯ К НИМ СПОСОБЫ
专利权人:
КЬЮБИСТ ФАРМАСЬЮТИКАЛЗ; ИНК. (US)
发明人:
ОКОННОР Сандра (US),САН Софи (US),НАИК Гааури (US)
申请号:
RU2013157188/15
公开号:
RU2013157188A
申请日:
2012.05.24
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. The solid preparation of CB-183,315, containing CB-183,315 and at least one sugar selected from sucrose, trehalose and dextran, wherein said solid preparation is prepared posredstvoma. forming an aqueous solution of CB-183,315 and sugar and b. conversion of the aqueous solution (a) in solid preparat.2. The solid preparation of CB-183,315 according to claim 1, wherein in the range of about at least 1 weight ratio CB-183,315 to sugar mass in step (a.): 0.5 to about 1: 2.3. The solid preparation of CB-183,315 according to Claim. 1, wherein the aqueous solution of step (a) is converted into a solid preparation in step (b) by lyophilization, spray drying, fluid bed drying or spray naslaivaniya.4. The solid preparation of CB-183,315 according to Claim. 1 obtained posredstvoma. forming an aqueous solution containing CB-183,315 and sugar selected from sucrose or trehalose, wherein the mass ratio of CB-183,315 the weight of the sugar is in the range of about at least 1: 0.5 to about 1: 2, at a pH of about 2-7, and b. converting aqueous CB-183,315 step (a) into a solid preparat.5. A method of manufacturing the solid preparation of CB-183,315, vklyuchayuschiya. forming an aqueous solution containing CB-183,315 and sugar selected from sucrose or trehalose, wherein the mass ratio of CB-183,315 the weight of the sugar is in the range of about at least 1: 0.5 to about 1: 2, at a pH of about 2-7, and b. transformation aqueous CB-183,315 step (a) into a solid preparat.6. The form is a tablet, a capsule, a sachet or an oral dosage form containing the composition according to any one of claims. 1-4.7. Form according to claim. 6, which is a tablet, capsule, sachet or oral dosage form further comprises1. Твердый препарат CB-183,315, содержащий CB-183,315 и, по меньшей мере, один сахар, выбранный из сахарозы, трегалозы или декстрана, где указанный твердый препарат получают посредствомa. образования водного раствора CB-183,315 и сахара иb. преобразования водного раствора (а) в твердый
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