The present disclosure provides novel solid CB-183,315 formulations which have improved chemical stability. The chemical stability of the solid CB-183,315 is dependent on the process by which the composition is made. Solid preparations of CB-183,315 can be prepared by the following method: (a) forming an aqueous solution of CB-183,315 and at least one sugar that (e.g., sucrose, trehalose or dextran) at a pH of 2-7, preferably pH 6 and (b) converting the aqueous solution to the solid preparation of CB-183,315 (e.g., via lyophilization or spray drying).本揭示內容提供具有改良化學穩定性之新穎固體CB-183,315調配物。該固體CB-183,315之化學穩定性取決於製備組合物之製程。可藉由下列方法來製備CB-183,315之固體製劑:(a)形成CB-183,315及至少一種糖(例如,蔗糖、海藻糖或葡聚糖)之pH為2至7,較佳地pH為6之水溶液,及(b)將該水溶液轉化成CB-183,315之該固體製劑(例如,經由凍亁或噴霧亁燥)。
