Disclosed herein are methods and compositions related to the treatment and/orameliorationof diseases and conditions comprising administration of SkQ compounds, and/ornaturally orartificially occurring derivatives, analogues, or pharmaceutically acceptablesalts thereof. Inparticular, the present technology relates to administering an effectiveamount of SkQcompound to a subject in need thereof to prevent or treat a disease or medicalcondition,reduce risk factors associated with a disease or medical condition, and/orreducing theseverity of a medical disease or condition.