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CONJUGUÉ POLYMÈRE À BASE D'UN COMPLEXE DE PLATINE (II) COORDONNÉ À UN DÉRIVÉ DE SULFOXYDE
专利权人:
Nippon Kayaku Kabushiki Kaisha
发明人:
NAKAMURA Masaharu,FUKUDA Tsuyoshi,YAMAKAWA Ken,KATO Takuya
申请号:
EP16878558
公开号:
EP3395857A4
申请日:
2016.12.16
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
A DDS preparation of a platinum complex, which exhibits a superior antitumor effect required as a medicine and reduced side effects, that is, a clinically usable DDS preparation of a platinum complex, which is conjugated to a polymer carrier that is different from conventional carriers, is desired. Provided is a polymer conjugate of a platinum(II) complex, the polymer conjugate including: a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; a sulfoxide derivative introduced into a side-chain carboxyl group of the block copolymer; and a platinum(II) complex coordinate-bonded to a sulfoxide group of the sulfoxide derivative.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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