LIN, JEN CHENG,LIN, CHUN-CHIEH,LEE, HSU-TUNG,FAN, YU-MING,TSAI, JUI-CHI,DU, YING-CHI
申请号：
CA2975000
公开号：
CA2975000A1
申请日:
2016.01.27
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to a novel type of PPAR? modulator having a pyrimido [5, 4-d]pyrimidine main structure. The PPAR? modulator can enhance the expression and nuclear translocation of PPAR? in cells. The present invention also relates to a pharmaceutical composition comprising the PPAR? modulator of the invention encapsulated in a pharmaceutically acceptable cell-penetrating drug delivery system so that it can be directly delivered into cells. The present invention thus provides a method of preventing or treating PPAR?-related disorders or conditions comprising administering to a subject in need thereof a therapeutically effective amount of the PPAR? modulator of the invention or the pharmaceutical composition of the invention.
