In part, one aspect of the invention relates to a portable, handheld biosensor device that is held between two fingers of the same hand or otherwise contacts two points on a user's skin. The sensor device includes a pair of conductive or semi-conductive electrodes and associated circuitry designed to sense, amplify and digitize the electrical conductance of the skin between the electrodes. The device can additionally be configured to sense additional biometrics from the fingers, including blood oxygenation and skin temperature. Digitized biometric values are transmitted wirelessly (or via direct wire connection, such as a USB cable) to a computing device where the data is utilized to generate a control parameter in a software application whose purpose is to provide anxiety biofeedback or entertainment.