Compositions and preparations of fetal support tissue that prevent or reduce the proliferation and epithelial-mesenchymal transition (EMT) of epithelial cells, wherein the epithelial cells may be human epithelial cells and the human epithelial cells may be conjunctival, retinal, corneal, limbal, or renal epithelial cells. Methods of preventing or reducing the proliferation, cell migration, and EMT of epithelial cells in an individual in need thereof, wherein the epithelial cells may be human epithelial cells and the human epithelial cells may be conjunctival, retinal, corneal, limbal, or renal epithelial cells. Methods of preventing or treating proliferative vitreoretinopathy in an individual in need thereof.本發明提供防止或減少上皮細胞增生及上皮-間質轉移(EMT)之組合物及胎兒支持組織製劑，其中該等上皮細胞可為人類上皮細胞且該等人類上皮細胞可為結膜、視網膜、角膜、角膜緣或腎上皮細胞。本發明提供防止或減少有需要之個體中之上皮細胞增生、細胞遷移及EMT的方法，其中該等上皮細胞可為人類上皮細胞且該等人類上皮細胞可為結膜、視網膜、角膜、角膜緣或腎上皮細胞。本發明提供預防或治療有需要之個體中之增生性玻璃體視網膜病變的方法。
