Massachusetts Eye and Ear Infirmary;The Children's Medical Center Corporation
发明人:
Pedram Hamrah,Ulrich von Andrian,Aslihan Turhan
申请号：
US15669673
公开号：
US20180142017A1
申请日:
2017.08.04
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are methods for reducing corneal inflammation, reducing inflammatory cell (e.g., dendritic cell) recruitment to the cornea, and treating an corneal inflammatory disorder in a subject that include administering to the subject one or more of a MadCAM-1 antagonist, an α4β7 integrin antagonist, a L-selectin antagonist, and an E-selectin antagonist. Also provided are compositions containing one or more of a MadCAM-1 antagonist, an α4β7 integrin antagonist, a L-selectin antagonist, and an E-selectin antagonist, and kits containing these compositions.
