A device (400, 700) for facilitating passage of a substance through skin (108) on the body of a subject, comprising: a non-conductive frame (410, 710) an electrode (420) fixed to the frame (410, 710) and shaped so as to define a skin-contact electrode surface (752) and a control unit (130), configured to drive the electrode (420) to apply an electric current to the skin (108) capable of ablating stratum corneum epidermidis thereof, so as to facilitate passage through the skin of the substance characterized in that: the frame (410, 710) is shaped so as to define a protrusion having a skin-contact frame surface (422, 750) that protrudes relative to an underside of the frame (410, 710) facing the skin.(108) and the electrode (420) passes through the protrusion such that the electrode surface (752) protrudes beyond the frame surface (422, 750).
