An eco-friendly disinfection system according to the present invention is a disinfection system which sterilizes a vehicle which is driven on a road and a structure which is installed on the road so that the paved surface of the road of a disinfection section can be protected and a prevention medicinal substance can be collected and recycled. The eco-friendly disinfection system includes: a paved surface waterproofing layer which is formed with a reactive resin matter in order to prevent a medicinal substance which is sprayed from medicinal substance spraying equipment from directly reacting to a road by being arranged on the surface of the road at a regular interval; a pair of speed bumps which are arranged to be separated in the longitudinal direction of a road across the medicinal substance spraying equipment and are extended in the width direction of the road in order to block the flow of liquid medicinal substance which is sprayed on the paved surface waterproofing layer; a medicinal substance leakage blocking pad which is arranged in the longitudinal direction of the road in order to connect an end part of the pair of speed bumps, is installed on the paved surface waterproofing layer, and blocks the medicinal substance from being exposed toward the lateral side of the road; and a medicinal substance collecting module which collects a medicinal substance, which is accommodated in a disinfection zone which is a space which is formed by a pair of overspeed bumps and the medicinal substance leakage blocking pad, and sends the medicinal substance to the medicinal substance spraying equipment.본 발명에 따른 친환경 방역 시스템은, 방역구간의 도로 포장면 보호와 방제약물 회수 및 재사용이 가능하도록 도로에 설치되는 구조물을 포함하여 그 도로를 운행하는 차량을 소독하는 방역 시스템으로서, 상기 도로의 표면 위에 일정 구간 배치되어 약물 살포장치로부터 살포되는 약물이 도로와 직접적으로 반응하는 것을 차단하도록 반응성 수지 물질로 형성된 포장면 방수층; 상기 약물 살포장치를 사이에 두고 도로의 길이방향으로 이격 되도록 배치되며 상기 포장면 방수층에 살포된 액상 약물의 흐름을 차단하도록 도로의 폭 방향으로 연장된 한 쌍의 과속 방지턱; 상기 한 쌍의 과속 방지턱의 일단부를 연결하도록 도로의 길이방향으로 배치되고, 상기 포장면 방수층 위에 설치되며, 도로의 측면 쪽으로