COMPOSES A BASE D'OLIGONUCLEOTIDE IMMUNOSTIMULANTE AVEC DINUCLEOTIDES A LIAISON GLYCEROL ET GUANOSINES MODIFIEES A CPG ET LEURS UTILISATIONS

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专利权人:

IDERA PHARMACEUTICALS

发明人:

AGRAWAL, SUDHIR,YU, DONG,KANDIMALLA, EKAMBAR R.

申请号：

CA2628306

公开号：

CA2628306C

申请日:

2005.11.07

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The invention relates to the therapeutic use of oligonucleotides asimmunostimulatory agents in immunotherapy applications. More particularly, theinvention provides immunostimulatory oligonucleotides for use in methods forgenerating an immune response in a vertebrate, and for use in treating orpreventingimmune-related disorders, cancer, and other diseases or disorders. Theimmunostimulatory oligonucleotides of the invention preferably comprise novelpurines. The immunostimulatory oligonucleotides according to the inventionfurthercomprise at least two 11-mer oligonucleotides linked by glycerol at their 3'ends, andhaving a CpG moiety comprising a modified guanosine.

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http://www.ckcest.cn/home/