A jaw closure mechanism for use in a surgical clip applier having first and second jaws movable relative to one another between a spaced-apart position and an approximated position to form a surgical clip about tissue. The jaw closure mechanism includes first and second eccentric wheels rotatably coupled to the respective first and second jaws. Each of the wheels includes a center and a pivot point that is offset relative to the center. A cable is disposed about each of the wheels. The cable is engaged to the first wheel at a first engagement point and to the second wheel at a second engagement point such that, upon application of a drive force to the cable, the wheels are rotated and displaced relative to the respective jaws from a first position to a second position to urge the jaws from the spaced-apart position to the approximated position.
