Allen J. Ebens, Jr.;Frederic S. Jacobson;Susan D. Spencer;Paul Polakis;Allen J. Ebens;Mark X. Sliwkowski; Jr.;Ralph H. Schwall
发明人:
Allen J. Ebens, Jr.,Frederic S. Jacobson,Paul Polakis,Ralph H. Schwall,Mark X. Sliwkowski,Susan D. Spencer
申请号：
US12326721
公开号：
US08142784B2
申请日:
2008.12.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to antibody-drug conjugate compounds of Formula I:Ab-(L-D)p Iwhere one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.
