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ACYLAMINOTHIAZOLE DERIVATIVES AND USE THEREOF AS BETA-AMYLOID INHIBITORS
专利权人:
发明人:
BALTZER SYLVIE,VAN DORSSELAER VIVIANE,PASCAL MARC
申请号:
IN1943/KOLNP/2006
公开号:
IN252043B
申请日:
2006.07.11
申请国别(地区):
IN
年份:
2012
代理人:
摘要:
The invention relates to a compound having general formula (I), wherein: R1 represents either an optionally-substituted C1-6 alkyl or a C3-7cycloalkyl, a thiophene, a benzothiophene, a pyridinyl, a furanyl or a phenyl, said phenyl groups being optionally substituted; R2 and R'2represent, independently of each other, a hydrogen atom, a halogen atom, a hydroxy, a C1-3 alkoxy, a C1-3 alkyl, a C3-7 cycloalkyl, an O-C(O)-C1-6alkyl group, or R2 and R'2 together form an oxo group; R3 represents either a hydrogen atom or an optionally-substituted C1-6 alkyl; R4 and R5 represent, independently G J of each other, a hydrogen atom, a C1-7 alkyl, ' M (L) a trifluoromethyl, an L group or a Z group; G represents a C1-7 alkyl or a single bond; M represents a C3-7 cycloalkyl, a phenyl, a naphtyl or a pyridinyl, group M being optionally substituted; J represents a hydrogen atom or a group -Y-K; Y represents a single bond, an oxygen atom, a sulphur atom, an optionally-substituted -C1-4alkylene- group, -O-C1-4 alkylene-, -C1-4 alkylene-O- or -N(W); K represents a phenyl or pyridinyl group, group K being optionally substituted, with the proviso that at least one R4 or R5 group represents a Z group; and Z represents a group CN, SO2NR6R7, or a heteroaromatic group, said heteroaromatic group being optionally substituted. The inventive compound takes: the form of a base, an acid addition salt, a hydrate or a solvate. The invention also relates to the use of said compound in therapeutics.
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