An ophthalmic system is provided that includes an ophthalmic imaging device to generate an image of a portion of an imaged eye of a patient, an image processor to determine a misalignment of the imaged eye and the imaging device by processing the generated image, and to generate a control signal according to the determined misalignment, and a misalignment-reduction system to receive the control signal, and to generate a misalignment-reduction response. The misalignment-reduction system can include a fixation light system or a gantry. In some cases a locator light system may provide additional alignment information for the image processor.