The present invention relates to a kind of ophthalmically acceptable ion-transmission devices for any ionized drugs solution (such as riboflavin solution) being transmitted to cornea, which includes: being suitable for being merely positioned the storage cavern (8) containing riboflavin solution on eyes Be arranged in storage cavern (8) or storage cavern (8) on active electrode (2) And it is suitably positioned on the skin of subject, the Passive electrode of the preferred ocular vicinity in other positions of body (such as forehead, cheek or neck) Anterior corneal surface is irradiated to realize the combination of the device (10) of corneal cross-linking with suitable light (such as ultraviolet light) after transmission drug or riboflavin Wherein the storage cavern (8) and the active electrode (2) are transparent to ultraviolet light and/or visible light and/or infrared light. The invention further relates to a kind of ophthalmically acceptable ion-transmission devices by means of according to appended claims to be transmitted to cornea to treat keratoconus or any other disease of cornea or the method to reinforce corneal stroma structure any ionized drugs solution (such as riboflavin solution), method includes the following steps: the ion-transmission device for including the storage cavern containing riboflavin solution is located on eyes to be treated By applying cathode current under the current strength not higher than 2mA up to 0.5 to 5 minutes and drive solution motion Ultraviolet light is used, up to 5 to 30 minutes, to be achieved in the corneal cross-linking of riboflavin with 3 to 30mW/cm2 power illumination anterior corneal surface immediately after electric current applies.
