According to an embodiment of the present invention, there is provided a method for determining whether the brain is fatigued, the method comprising: collecting electroencephalogram signals of a testee； quantifying the electroencephalogram signals utilizing a sample entropy algorithm to obtain a final sample entropy value of the electroencephalogram signals； determining whether the brain of the testee is fatigued according to the final sample entropy value, wherein it is determined that the brain of the testee is in a fatigue state when the final sample entropy value is within a predetermined range. According to an embodiment of the present invention, there is also provided an apparatus for executing the method hereinabove. A sample entropy algorithm may be utilized to calculate a sample entropy value of electroencephalogram signals, and the degree of fatigue of the testee's brain can be objectively and accurately evaluated according to the sample entropy value.
