SEIDERS, THOMAS JON,WANG, BOWEI,HUTCHINSON, JOHN HOWARD,STOCK, NICHOLAS SIMON,VOLOTS, DEBORAH
申请号：
PE2013001366
公开号：
PE20140879A1
申请日:
2011.12.06
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to formula compound (I): R1 is CO2H, C (= O) nh-oh, P (= O) (OH) 2, CN, etc.； L1 is missing, or tar C1-C6, cyclopropene C3-C6, etc.； cycloa is phenyl, northwest non-n-propene, monocyclic isopropene or monocyclic isopropene, provided that cycloa is not an isomer； RA and Rb are independent CN, hehe, C1-C4, among others； L2 is a C1-C6 tar, C1-C6 fluoroquino C1-C6 is substituted or not substituted； R2 is a C1-C6 tar, C1-C6 fluoro, C1-C6 fluoro, C3-C10 cyclopropyl compound is substituted or not substituted； R3 is an integer of C1-C4, C1-C4 fluoro or C3-C6 cyclopropyl compound；N is a complete 0 to 2. The most popular compounds are: acid 1 - (4 - {4 - [1 - (2-chloro-phenyl) - acetamide] - pyridine-3-il} - diphenyl-4-il) - cyclopropane； acid 1 - {4 - [1-methyl-5 - (6-phenyl-pyridine-2-acetamide) - 1h-pyrazol-4-il] - diphenyl-4-il] - cyclopropene, etc. And pharmaceutical composers These compounds can be used to treat cancer, organ fibrosis, liver diseases.SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: R1 ES CO2H, C(=O)NH-OH, P(=O)(OH)2, CN, ENTRE OTROS； L1 ESTA AUSENTE, O ES ALQUILENO C1-C6, CICLOALQUILENO C3-C6, ENTRE OTROS； EL ANILLO A ES FENILO, NAFTILO, HETEROARILO MONOCICLICO, O HETEROARILO BICICLICO, SIEMPRE QUE EL ANILLO A NO SEA UN ISOXAZOL； Ra Y Rb ES INDEPENDIENTEMENTE CN, OH, ALCOXI C1-C4, ENTRE OTROS； L2 ES UN ALQUILENO C1-C6, FLUOROALQUILENO C1-C6 SUSTITUIDOS O NO SUSTITUIDOS, ENTRE OTROS； R2 ES ALQUILO C1-C6, FLUORO C1-C6, CICLOALQUILO C3-C10 SUSTITUIDO O NO SUSTITUIDO, ENTRE OTROS； R3 ES ALQUILO C1-C4, FLUOROALQUILO C1-C4 O CICLOALQUILO C3-C6； m ES UN ENTERO DE 0 A 2； n ES UN ENTERO DE 0 A 2. SON COMPUESTOS PREFERIDOS: ACIDO 1-(4�-{4-[1-(2-CLORO-FENIL)-ETOXICARBONILAMINO]-PIRIDIN-3-IL}-BIFENIL-4-IL)-CICLOPROPANCARBOXILICO； ACIDO 1-{4�-[1-METIL-5-(6-FENIL-PIRIDIN-2-ILAMINO)-1H-PIRAZOL-4-IL]-BIFENIL-4-IL}-CICLOPROPANCARBOXILICO； ENTRE OTROS. REFERIDO ADEMAS A COMPOSICIONES FARMACEUTICAS. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE CANCER, FIBROS
