FENSOME ANDREW,GOPALSAMY ARIAMALA,GERSTENBERGER BRIAN S.,EFREMOV IVAN VIKTOROVICH,WAN ZHAO-KUI,PIERCE BETSY,TELLIEZ JEAN-BAPTISTE,TRUJILLO JOHN I.,ZHANG LIYING,XING LI
申请号：
SV2017005384
公开号：
SV2017005384A
申请日:
2017.02.16
申请国别(地区):
SV
年份:
2017
代理人:
摘要：
1. Structural compounds (see formula)；Or a pharmaceutically acceptable salt, where x is n or Cr, R is hydride, deuterium, C1-C4 tar, C1-C4 oxygen, C3-C6 cyclopentadiene, arilo, isopropene, aril (C1-C6 tar),Cn, amino, privatamino, diaklamino, CF3, O hydroxilo； a selected from the contact group, C = O, SO2 -,- (C = O) NR0--,And -- (crarb) Q--Among them, R0 is h or C1-C4 tar, RA and Rb are independent hydrogen compounds, deuterium, C1-C6 tar, C3-C6 cyclopentadiene, arilo, aril (C1-C6 tar),1. Non normal propylene (C1-C6 tar), etc；A 'selected from the contact group, C = O, SO2 -',- (C 3DO) NR0- NR0 (C 3DO) -And -- (cra'rb) Q--Where 0's h or C1-C4 tar, and RA 'and Rb' are independent hydrogen, deuterium, C1-C6 tar, C3-C6 cyclododecane, arilo, aril (C1-C6 tar),Heterosexual (C1-C6 tar), heterosexual (C1-C6 tar),(c) Isopropene (C1-C6 tar)；Z is - (CH2) H - or link, in which one or more methamphetamine units are replaced by one or more C1-C3, CN, O H, methoxi or halotars, and tar can be replaced by one or more fluorine atoms； the selection of R1 and R1's does not consider the group composed of hydrogen, deuterium, C1-C4 tar, C3-C6 cyclopentanediol, arilo, isopropene, aril (C1-C6 tar)Wait, waitIn this case, asphalt, arilo, cyclopentyl, isopropyl or heterogeneous asphalt is replaced by one or more alternatives selected from C1-C6, halo, CN, C1-C4 lease, C3-C6 cyclopentyl and other substances；R2 is selected from the hydrogen, deuterium, C1-C6 tar, C3-C6 cyclododecane, halogen and cyanogen groups, in which one or more fluorine atoms can be used instead of tar； R3 is selected from the hydrogen, deuterium and ammonia groups； R4 is a singular or singular or singular or singular or even number of arilo, in which case arilo or heterosexual is replaced by one or more C1-C6 tar, isocyclic tar, halo, C3-C6 cyclopropyl tar and other substances.There, tar, cyclopentanediol, propylene oxide or isocyclopropylene can be replaced by one or more C1-C6, halogen, CN, oh, alcoxi, amino, - CO2H, - N
