Disclosed in the present invention is an eye drop for treating eye dryness. With a pH value of 5.0-7.0, the eye drop comprises the following components in percentage by weight: 0.05-0.1% of an active component 5-hydroxy-1-beta-D-furanosyl-1H-imidazole-5-carboxamide, an appropriate amount of a pH regulator, 0.01-3% of an isotonic agent, 0.003-0.5% of a bacteriostatic agent, 0.001-0.5% of a stabilizer, 0.01-0.5% of a tackifier, 2-5% of a solubilizer, and the balance of water. The eye drop provided by the present invention can protect the epithelial barrier function of the corneas of mice with eye dryness, increase the number of goblet cells of the corneas, and achieve relatively good anti-inflammatory and immunosuppressive effects.
