재단법인 대구경북첨단의료산업진흥재단;한국과학기술연구원;DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION;KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
SIM, TAE BO,심태보,HUR, WOO YOUNG,허우영,SONG, CHI MAN,송치만,YOON, HO JONG,윤호종,CHOI, SEUNG HYE,최승혜,CHO, HAN NA,조한나,CHOI, HWAN GEUN,최환근,KIM, NAM DOO,김남두,SON, JUNG BEOM,손정범,KO, EUN HWA,고은화,KIM, HYUN KYOUNG,김현경,SIM, TAE BOKR,HUR, WOO YOUNGKR,SONG, CHI MANKR,YOON, HO JONGKR,CHOI, SEUNG HYEKR,CHO, HAN NAKR,CHOI, HWAN GEUNKR,KIM, NAM DOOKR,SON, JUNG BEOMKR,KO, EUN HWAKR,K
申请号：
KR1020170020896
公开号：
KR1020170096599A
申请日:
2017.02.16
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a novel 2,3,5-substituted thiophene compound having inhibitory activity against kinases, an anticancer agent comprising the compound as an active ingredient, and a method of preparing the compound. According to the present invention, the 2,3,5-substituted thiophene compound has inhibitory activity on the proliferation of FLT3-ITD-positive leukemia cell line and Ba/F3 cell line, and has superior inhibitory activity on drug-resistant FLT3 mutations as well, and thus is effective in the treatment of acute myeloid leukemia.본 발명은 키나아제 저해 활성을 가지는 신규의 2,3,5-치환된 싸이오펜 화합물과 상기 화합물을 활성성분으로 포함하는 항암제, 그리고 상기 화합물의 제조방법에 관한 것이다.
