The present invention relates to a pharmaceutical composition comprising: a. From about 0.2% w / w to about 20.0% w / w D-(+)-trehalose dihydrate and b. From about 0.1% w / w to about 10.0% w / w C. Between about 0.01% w / w and 0.3% w / w polyoxyethylene sorbitan monooleate and d. Between about 1.0 nM and about 500 mM, between about 4.0 and about From about 1.0% w / w to about 5.0% w / w, exclusively between about 0% w / w and about 0.5% w / w 5-chloro-2-methyl-4-isothiazolin-3-one in between about 0.1% w / w and about 3.0% w / w 2-methyl-4-isothiazolin-A composition for preserving at least one biomolecule comprising an agent solution.本発明は、a. 約0.2% w/w~約20.0% w/wの間のD-(+)-トレハロース二水和物;及びb. 約0.1% w/w~約10.0% w/wの間のD-マンニトール;c. 約0.01% w/w~0.3% w/wの間のポリオキシエチレンソルビタンモノオレエート;及びd. 約1.0 nM~約500 mMの間の、約4.0~約8.0の間のpHのクエン酸ナトリウム;及びe. 厳密に約0% w/wより大きく、約0.5% w/wまでの間の、i. 約1.0% w/w~約5.0% w/wの間の5クロロ-2メチル-4-イソチアゾリン-3-オン;及びii. 約0.1% w/w~約3.0% w/wの間の2-メチル-4-イソチアゾリン-3-オンを含む防腐剤溶液を含む、少なくとも1種の生体分子を保存するための組成物に関する。