Devices and methods for screening for ovarian and endometrial cancer are disclosed. The device includes a catheter positioned to enter an endometrial cavity of the patient. The device can include a transvaginal probe configured to be inserted into a vagina of the patient, and a needle both coupled to the transvaginal probe. The needle can be is positioned to enter a cul-de-sac of the patient when the transvaginal probe is inserted into the vagina, and into the cul-de-sac, and the needle is configured to collect the fluid from the cul-de-sac. The catheter can also configured to deliver fluid into the endometrial cavity. The fluid can also be a dye injected into the endometrial cavity and absorbed by the endometrial carcinoma and that drains into at least one sentinel lymph node. The sentinel lymph node can be identified to allow for dissection and further examination for micrometastasis.
