A system and method for integrating diagnosis and treatment for internal tissues includes imaging (202) at least a portion of an internal organ of a subject using a first technology capable of differentiating tissue types, and targeting (205) and accessing biopsy sites using images of the first technology fused with images of a second technology capable of real-time image updates. Treatment of a biopsy site is planned (207) using the images of the first technology. Instruments for treating the biopsy site are guided (210) by fusing (208) the images of the first technology with the images of the second technology.
