A closure device for a body passageway of a patient includes a plug member formed from an extracellular matrix material. The plug has a compressed condition, and is modifiable therefrom to an expanded condition for occluding the body passageway. A plurality of first frame members is disposed along a first side of the plug. The first frame members are aligned in a first position relative to the plug when the plug is in the compressed condition, and movable therefrom to a second position for occlusion of the passageway. A plurality of second frame members is disposed generally along a second side of the plug. The second frame members are aligned in a first position relative to the plug when the plug is in the compressed condition, and movable therefrom to a second position for occlusion of the passageway.
