The present invention discloses a multifunctional temperature self-regulating multilayer film, from outside to inside comprising at least: a carrier layer (1) loaded with functional material, and a thermal-insulation layer (2) directly contacted with the skin (4); wherein the carrier layer (1) loaded with functional material has a sealed cavity sealed with a flexible water-impermeable material, the sealed cavity is at least loaded with a refrigerating or heat-generating chemical material (11); wherein thermal-insulation layer (2) is made of a material having waterproof and thermal-insulation properties. The present multilayer film can be manufactured into a face mask or eye mask for use on facial skin.