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Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals
专利权人:
Hans Matter;Gary McCort;Hans Ulrich Stilz;Henning Steinhagen;Bodo Scheiper
发明人:
Henning Steinhagen,Bodo Scheiper,Hans Matter,Hans Ulrich Stilz,Gary McCort
申请号:
US12845317
公开号:
US08211885B2
申请日:
2010.07.28
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention relates to cyclic indole-3-carboxamides of the formula I,wherein A, R, R10, R20, R30, R40, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
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