ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
发明人:
PORCELLI, STEVEN, A.
申请号：
EP05808439
公开号：
EP1784196A4
申请日:
2005.08.26
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
&alpha；-Galactosylceramides and glycosylceramides (&ldquo；ceramide-like glycolipids&rdquo；) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the antigen-presenting cells that are capable of efficiently presenting the compounds to NK T cells. Pharmaceutical compositions of the ceramide-like glycolipids are provided, as are pharmaceutical compositions of the ceramide-like glycolipids combined with dendritic cells. Methods utilizing the ceramide-like glycolipids in vaccines, to activate NK T cells, to stimulate the immune system, and to treat mammals are also provided. The invention also provides methods of evaluating a compound for its ability to activate an NK T cell in the presence of a cell expressing a CD1d protein.
