改良免疫毒素を用いた癌治療法

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专利权人:

ユニバーシティー オブ チューリッヒ

发明人:

ツァンゲマイスター-ウィトケ ウヴェ,ディ パオロ クラウディオ

申请号：

JP2007555528

公开号：

JP5014157B2

申请日:

2006.02.16

申请国别(地区):

JP

年份:

2012

代理人:

摘要：

The present invention provides a modified toxin having an ETA moiety that has the furin site replaced with a cancer-associated protease site. The present invention also provides modified immunotoxins having a ligand that binds to a cancer cell attached to an ETA moiety that has the furin site replaced with a cancer-associated protease site. Also provided are a method of inhibiting or destroying mammalian cancer cells using the immunotoxins of the invention and pharmaceutical compositions for treating human cancer.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/