This invention provides a suture system and method that does not require knots. A locking suture includes a needle and a thread that is provided with a plurality of locking barbs. The needle is applied over an end of the thread by conventional systems. The exterior surface of the thread is covered with barbs. The barbs can be arranged in rows of at least one barb each, circumscribing the thread of the suture and are oriented so that they are uniformly feathered, being closed in the direction of the needle and open toward the terminal (posterior) end. The feathering provides for the barbs to lie flat when drawn through a membrane or other material, and the bias causes them to splay open when a tension towards the terminal/posterior end is exerted. This splaying creates a locking force.