To provide an agent for the prevention or treatment of Gb3 accumulation-attributable disease such as Fabry disease, and heart disease with abnormal heart stroke.SOLUTION: The present invention provides an agent for the prevention or treatment of Gb3 accumulation-attributable disease containing at least one selected from the group consisting of a chloroquine represented by the following formula and a chloroquine derivative.SELECTED DRAWING: None【課題】ファブリー病、及び心臓拍動異常を伴う心臓病等のGb3蓄積起因性疾患の予防又は治療剤を提供。【解決手段】下式に示すクロロキン及びクロロキン誘導体からなる群より選択される少なくとも1種を含有する、Gb3蓄積起因性疾患の予防又は治療剤。【選択図】なし