РЕЙЗНЕР Яйр (IL),ОФИР Еран (IL),ЭЙДЕЛШТЕЙН Яки (IL),БАЧАР-ЛУСТИГ Эстер (IL)
申请号：
RU2011121630/10
公开号：
RU2011121630A
申请日:
2009.10.29
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. An isolated population of cells, including non-GVHD inducing cells against a third party, having a phenotype of central memory T-lymphocytes (Tcm), said central memory T-lymphocytes (Tcm) containing the signature CD8, CD62L, CD45RA, CD45 RO, and wherein, at least 50% of the isolated cell population has the specified signature, and these cells are cells that induce tolerance and capable of homing into the lymph nodes after transplantation. 2. The isolated cell population of claim 1 for use in treating a human subject in need thereof, said disease being selected from the group consisting of a malignant disease, a viral disease, and an autoimmune disease. The isolated cell population of claim 1 for use as an adjuvant treatment in cell or tissue transplantation to a human subject in need of cell or tissue transplantation. An isolated cell population according to claim 3, wherein said isolated cell population is administered before, simultaneously with or after said cell or tissue transplant. The isolated cell population of claim 3, wherein said isolated cell population is syngeneic to the subject. The isolated cell population according to claim 3, wherein said isolated cell population is nonsingen in relation to the subject. The isolated cell population of claim 3, wherein said cell or tissue transplant is obtained from a donor selected from the group consisting of an HLA-identical allogeneic donor, an HLA-non-identical allogeneic donor, and a xenogenic donor. Isolated cage population1. Изолированная популяция клеток, включающая не индуцирующие GVHD клетки против третьей стороны, имеющие фенотип Т-лимфоцитов центральной памяти (Tcm), причем указанные Т-лимфоциты центральной памяти (Tcm) содержат сигнатуруCD8, CD62L, CD45RA, CD45 RO, и причем, по меньшей мере, 50% изолированной популяции клеток имеет указанную сигнатуру, причем указанные клетки являются клетками, индуцирующими толерантность и способными к хоумингу в лимфоузлы после трансплантации.2. Изолированная попу
