PROBLEM TO BE SOLVED: To provide a hollow fiber membrane for blood purification, in which a hole is not blocked due to protein absorption even when blood or plasma is processed and high substance elimination performance can be maintained even after a long period of use, and which has a hole size capable of eliminating substances in a molecular weight area including the protein, and to provide a method for manufacturing it.SOLUTION: The hollow fiber membrane for blood purification has a hydrophilic polymer on an inner wall of the hollow fiber membrane including a hydrophobic polymer, while its block ratio of albumin is 5 to 95%. Further, the manufacturing method of the hollow fiber membrane for blood purification includes a process for manufacturing the membrane in the hollow fiber state by dispensing an undiluted solution for manufacturing the membrane, which contains a hydrophobic polymer and a solvent, together with internal solidifying solution through a double ring nozzle into external solidifying solution, while the internal solidifying solution contains the hydrophilic polymer.COPYRIGHT: (C)2012,JPO&INPIT【課題】血液や血漿を処理してもタンパク質吸着による孔の閉塞が無く、長時間使用しても高い物質除去性能を維持することができ、タンパク質を含む分子量領域の物質を除去することができる孔サイズを持つ血液浄化用中空糸膜、及びその製造方法を提供する。【解決手段】疎水性高分子を含有してなる中空糸膜の内壁に親水性高分子を有してなり、アルブミン阻止率が5~95%である血液浄化用中空糸膜、並びに疎水性高分子及び溶媒を含有してなる製膜原液を内部凝固液とともに二重環状ノズルから外部凝固液中に吐出し、中空糸状に製膜する工程を含み、内部凝固液が親水性高分子を含有してなる液である、前記血液浄化用中空糸膜の製造方法。【選択図】なし
