Ms Aarti V Belgamwar,Dr Shagufta A Khan,Dr Pramod G Yeole
申请号：
IN201721004980
公开号：
IN201721004980A
申请日:
2017.02.12
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Incapability of antiretrovirals (ARV) in complete eradication of HIV from latent reservoir is the biggest issue in the treatment of neuro-AIDS. Considering this, the present study is focused to enhance the CNS uptake of dolutegravir sodium (DTG) by designing intranasal DTG-nanoparticles (DTG-NPs). Spherical shaped stable DTG-NPs with low particle size and high drug loading were prepared. Sustained release from the nanoparticles and enhanced permeation through the nasal mucosa of drug could be achieved without adverse effect on it. The present discloser enhance CNS delivery of DTG using DTG-NPs and high drug targeting index to the brain makes a promising gateway in Neuro-AIDS.
